Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss
Carolina E. Echeverría, Mujmmail Ahmed, Jonathan Gao, Sarah L Stewart, Isaac Nathoo, Lucas Kniess Debarba, Carlos Lafourcade, Tanvir Ahmed, Odinakhon Shamieva, Tiffany Perrier, Chandana Prakashmurthy, Anthony Escamilla, Philip Moon, Jeshua Kim, Rachel Zwick, , M Goncalves
This study shows that inhibiting fructose metabolism via KHKi reduces weight gain and enhances weight loss when combined with GLP-1 receptor agonism in mice.
bioRxiv · Jun 8, 2026 · PreprintCell Biology