Miriam Ferrer

JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake

This study shows that JAK1/2 inhibition with ruxolitinib improves survival and body weight in lung cancer models by increasing food intake and restoring metabolic function.

Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy

This study identifies Cystatin C as a glucocorticoid-responsive factor that recruits Trem2+ macrophages and predicts immunotherapy failure in cancer.

Tumor Cytokine-Induced Hepatic Gluconeogenesis Contributes to Cancer Cachexia: Insights from Full Body Single Nuclei Sequencing

The paper shows that tumor-secreted cytokines induce hepatic gluconeogenesis, contributing to hyperglycemia and poor prognosis in cancer cachexia using Drosophila and mouse models.

Area postrema neurons mediate interleukin-6 function in cancer-associated cachexia

This study identifies area postrema neurons as mediators of IL-6 function in cancer-associated cachexia, showing that targeting these neurons can prevent cachexia and prolong lifespan in mice.