Ferrous Iron Accumulation Is a Hallmark and Therapeutic Vulnerability of Therapy-Induced Senescence
Zhiming Wang, Yuanhui Liu, Hala S Hassanain, Yaopeng Ding, Shaoyang Zhao, Nancy Azizian, Yinan Gong, Keith Syson Chan, Jenny C. Chang, Mark Daniel Pegram, Yulin Li
This study identifies ferrous iron accumulation as a hallmark of therapy-induced senescence and shows that ferroptosis induction can eliminate residual tumor cells.
bioRxiv · May 23, 2026 · PreprintCancer Biology