Author

Sharon Brouwer

University Medical Center Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Akshaya Keerthi Saikumar JayalathaiD· 2 shared Gerard H. KoppelmaniD· 2 shared Judith M. VonkiD· 2 shared Maarten van den BergeiD· 2 shared Martijn C. NawijniD· 2 shared A Alexandros Imprachim· 1 shared Alexandra B. FirsovaiD· 1 shared Amanda J. OliveriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Akshaya Keerthi Saikumar JayalathaORCID

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2 papers

Recent·Most cited

A repair-associated bronchial epithelial differentiation trajectory through KRT14+ basal and hillock-like cells drives airway inflammation and remodelling in childhood-onset asthma

Tessa E. Gillett, Aurore C. A. Gay, Jelmer Vlasma, Alexandra B. Firsova, Martin Banchero, Anna Katharina Renner, Amanda J. Oliver, Marijn Berg, Sjors Maassen, Leonie Apperloo, Bao-Han Ly, Djoke van Gosliga, Marnix R. Jonker, Waradon Sungnak, Orestes A. Carpaij, , Martijn C. Nawijn

The paper identifies a novel asthma-associated epithelial differentiation trajectory involving KRT14+ basal cells and hillock-like cells that contributes to airway inflammation and remodelling in childhood-onset asthma.

bioRxiv · Sep 24, 2026 · PreprintImmunology

IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and disease status

Akshaya Keerthi Saikumar Jayalatha, Marlies E. Ketelaar, L Hesse, YE Badi, Nazanin Zounemat Kermani, Sharon Brouwer, F. Nicole Dijk, Maarten van den Berge, Victor Guryev, Ian Sayers, Judith M. Vonk, Ian Michael Adcock, Gerard H. Koppelman, Martijn C. Nawijn

The paper investigates how IL-33-induced gene expression in Th2 cells depends on IL-1RL1 haplotype and asthma status, finding stronger effects in risk haplotype carriers and a correlation with pauci-granulocytic asthma.

bioRxiv · Oct 20, 2022 · PreprintMolecular Biology