Author

Leonie Apperloo

University Medical Center Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:scRNA-seq· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Aurore C. A. GayiD· 2 shared Djoke van Gosliga· 2 shared Geert J.P.L. KopsiD· 2 shared Gerard H. KoppelmaniD· 2 shared Louis BontiD· 2 shared Maarten van den BergeiD· 2 shared Martijn C. NawijniD· 2 shared Martin BancheroiD· 2 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

Aurore C. A. GayORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Linking live-cell imaging to single-cell sequencing using genetic barcoding

Micha Muller, Silke J. A. Lochs, Leonie Apperloo, Rupa Banerjee, Joana R. Fernandes Marques, Carlota Davó-Martínez, Pim M. J. Rullens, Marta Moreno‐Gonzalez, Vasilis Papageorgiou, Bernhard A. Kramer, Geert J.P.L. Kops, Jop Kind, Marvin E. Tanenbaum

This paper introduces Waldo, a genetic barcoding system that links live-cell imaging phenotypes to single-cell sequencing data for the same cells.

bioRxiv · Oct 8, 2026 · PreprintCell Biology

A repair-associated bronchial epithelial differentiation trajectory through KRT14+ basal and hillock-like cells drives airway inflammation and remodelling in childhood-onset asthma

Tessa E. Gillett, Aurore C. A. Gay, Jelmer Vlasma, Alexandra B. Firsova, Martin Banchero, Anna Katharina Renner, Amanda J. Oliver, Marijn Berg, Sjors Maassen, Leonie Apperloo, Bao-Han Ly, Djoke van Gosliga, Marnix R. Jonker, Waradon Sungnak, Orestes A. Carpaij, , Martijn C. Nawijn

The paper identifies a novel asthma-associated epithelial differentiation trajectory involving KRT14+ basal cells and hillock-like cells that contributes to airway inflammation and remodelling in childhood-onset asthma.

bioRxiv · Sep 24, 2026 · PreprintImmunology

Pre-assembly of biomolecular condensate seeds drives RSV replication

Dhanushika Ratnayake, Marie Galloux, Sanne Boersma, Marko Noerenberg, Christina Sizun, Carlos Sacristán, Julien Sourimant, Anke J. Lakerveld, Anne T. Gelderloos, Leonie Apperloo, Yana Demyanenko, Matthijs J. D. Baars, Rupa Banerjee, Birgit Dreier, Sven Furler, , Marvin E. Tanenbaum

This study shows that RSV forms condensates by pre-assembling replication centers within viral particles, explaining infection heterogeneity and enabling efficient replication without requiring pre-existing condensates.

Nature · Jan 28, 2026Peer-reviewedMicrobiology

Airway epithelial response to RSV is impaired in multiciliated and goblet cells in asthma

Aurore C. A. Gay, Martin Banchero, Orestes A. Carpaij, Tessa Kole, Leonie Apperloo, Djoke van Gosliga, Putri Ayu Fajar, Gerard H. Koppelman, Louis Bont, Rudi W. Hendriks, Maarten van den Berge, Martijn C. Nawijn

This study examines the RSV response in bronchial epithelial cells from asthma patients and healthy donors, finding impaired antiviral responses in goblet and multiciliated cells in asthma.

bioRxiv · Mar 16, 2023 · PreprintMolecular Biology