APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
Kristine M. Tran, Nellie E. Kwang, Claire Ann Butler, Ángela Gómez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate Inman Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai‐Xuan Shi, , Kim N. Green
The paper investigates how the APOE Christchurch variant affects microglial responses to amyloid and tau pathology in mouse models, finding it enhances plaque-related responses but suppresses tau-related inflammation.
Molecular Neurodegeneration · Jan 22, 2025Peer-reviewedNeuroscience