Shimako Kawauchi

Hybrid crosses reveal a cell-type-specific landscape of mouse regulatory variation

The paper uses hybrid crosses to analyze regulatory variation in mouse tissues, finding cell-type-specific trans-acting effects and highlighting the limitations of bulk tissue analysis.

Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains captures global and local expression variation

The paper characterizes transcriptomes across 8 tissues in 8 mouse strains to identify expression variation linked to genetic differences and phenotypic traits.

Long-read sequencing transcriptome quantification with lr-kallisto

The paper develops lr-kallisto, a tool for accurate long-read transcriptome quantification using ONT data, showing improved results with exome capture.

Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia

The paper develops a mouse model to specifically target disease-associated microglia (DAMs) using an inducible Cre system and validates its specificity through spatial transcriptomic analysis.

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

The paper investigates how the APOE Christchurch variant affects microglial responses to amyloid and tau pathology in mouse models, finding it enhances plaque-related responses but suppresses tau-related inflammation.

A Trem2*R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's Disease

This paper characterizes the 3xTg-AD mouse model of Alzheimer's Disease across its lifespan and compares it with the 5xFAD model to assess pathology and model drift.

Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer's Disease

The paper performs a comprehensive phenotypic analysis of the 5xFAD mouse model across its lifespan, identifying novel age-related pathological features.

The cohesin loader NIPBL interacts with pre-ribosomal RNA and treacle to regulate ribosomal RNA synthesis

This study identifies NIPBL's interaction with RNA and treacle in regulating pre-rRNA transcription and nucleolar organization.

The Effect Of Nipped-B-Like (Nipbl) Haploinsufficiency On Genome-Wide Cohesin Binding And Target Gene Expression: Modeling Cornelia de Lange Syndrome

This study examines how Nipbl haploinsufficiency affects cohesin binding and gene expression in mice, linking reduced cohesin function to CdLS-related gene dysregulation.