The paper investigates how the APOE Christchurch variant affects microglial responses to amyloid and tau pathology in mouse models, finding it enhances plaque-related responses but suppresses tau-related inflammation.

Molecular Neurodegeneration · Jan 22, 2025Peer-reviewedNeuroscience

A Trem2*R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai‐Xuan Shi, Jonathan C. Neumann, , Kim N. Green

Molecular Neurodegeneration · Feb 17, 2023Peer-reviewedNeuroscience

Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's Disease

Dominic I. Javonillo, Kristine M. Tran, Jimmy Phan, Edna E. Hingco, Enikö A. Kramár, Celia da Cunha, Stefânia Forner, Shimako Kawauchi, Giedre Milinkeviciute, Ángela Gómez-Arboledas, Jonathan C. Neumann, Crystal E. Banh, Michelle Dieu Thao Huynh, Dina P. Matheos, Narges Rezaie, , Frank M. LaFerla

This paper characterizes the 3xTg-AD mouse model of Alzheimer's Disease across its lifespan and compares it with the 5xFAD model to assess pathology and model drift.

Frontiers in Neuroscience · Jan 24, 2022Peer-reviewedNeuroscience

Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer's Disease

Stefânia Forner, Shimako Kawauchi, Gabriela Balderrama-Gutierrez, Enikö A. Kramár, Dina P. Matheos, Jimmy Phan, Dominic I. Javonillo, Kristine M. Tran, Edna E. Hingco, Celia da Cunha, Narges Rezaie, Joshua A. Alcantara, David Baglietto‐Vargas, Camden S. Jansen, Jonathan C. Neumann, , Kim N. Green

The paper performs a comprehensive phenotypic analysis of the 5xFAD mouse model across its lifespan, identifying novel age-related pathological features.

Scientific Data · Oct 15, 2021Peer-reviewedNeuroscience