Z.H. Liu

Tirzepatide attenuates atherosclerosis through weight loss-independent anti-inflammatory mechanisms

This paper shows tirzepatide reduces atherosclerosis independently of weight loss by directly targeting vascular inflammation through the cAMP/PKA/eNOS pathway.

The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in Mycobacterium abscessus

This study identifies SigH as a key regulator of intrinsic antibiotic resistance in Mycobacterium abscessus through transcriptomic analysis and genetic complementation.

A biointegrated living brain stimulator evokes specific neural signalling

This paper introduces a biointegrated living brain stimulator that uses dopamine neurotransmitter-evoked signaling to restore motor function in a rodent Parkinson's disease model.

RNA sequencing resolves cryptic pathogenic variants in mitochondrial disease

This study uses RNA sequencing to identify pathogenic variants in mitochondrial disease patients who were undiagnosed by DNA sequencing, revealing cryptic splicing and regulatory events.

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex

The paper maps cis-regulatory elements in the macaque cortex using snATAC-seq and links them to disease-related genes and risk SNPs.

From genomic decay to functional advantage: Traits of a persistent, thermally beneficial coral probiotic

The paper identifies a coral probiotic strain with enhanced thermal tolerance and characterizes its genomic and functional traits associated with long-term host association.

IBDkb: an AI-enhanced integrative knowledge base for inflammatory bowel disease research and drug discovery

IBDkb integrates multi-source IBD data with AI tools to enhance research and drug discovery by enabling efficient exploration of drug-target-trial associations.

Re-polyadenylation occurs predominantly on maternal mRNA degradation intermediates during mammalian oocyte-to-embryo transition

The paper identifies re-polyadenylation of maternal mRNA degradation intermediates during mammalian oocyte-to-embryo transition using PAIso-seq data across species.

Dynamics of mitochondrial mRNA abundance and poly(A) tail during the mammalian oocyte-to-embryo transition

The paper studies mitochondrial mRNA abundance and poly(A) tail dynamics during the oocyte-to-embryo transition in multiple species, finding stable poly(A) tail length patterns and tissue-specific abundance changes.