DVT-primed neutrophils reshape the brain microenvironment to promote brain metastasis
Shun Endo, Denys Rujchanarong, Karen J. Keeran, Kenneth R. Jeffries, Wei Zhang, Maxwell Henry Bannister, Keita Saeki, Debbie Wei, Andy D. Tran, Kate Ellison, Anna Lee Fong, Langston Lim, Michael J. Kruhlak, Ross G. Lake, Christian A. Combs, , Takeo Fujii
This study shows that deep vein thrombosis (DVT) promotes brain metastasis in triple-negative breast cancer by reprogramming neutrophils to enhance vascular recruitment and NET formation.
bioRxiv · Sep 17, 2026 · PreprintMolecular Biology