Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming
Y Shen, Sofía Zaballa, Xavier Bech, Anna Sancho‐Balsells, Carmen Díaz-Cifuentes, Goenuel Seyit-Bremer, Iván Ballasch, Noelia Alcázar, Jordi Alberch, María Abad, Manuel Serrano, Rüdiger Klein, Albert Giralt, D del Toro
This study shows that transient Yamanaka factor expression during development expands the neocortex and improves cognitive function in mice, while intermittent expression in adult neurons protects against Alzheimer's disease features.
bioRxiv · Nov 27, 2023 · PreprintNeuroscience