Co-targeting an AMPK--MAPK axis reprograms CAFs and suppresses PDAC
Ryodai Yamamura, Yusuke Satoh, Junki Fukuda, Taku Kimura, Takuya Otsuka, Sho Sekiya, Taiga Hirata, Soichiro Hata, Reo Sato, Chihiro Kamijo, Takuya Moriguchi, Shinya Kosuge, Takuya Kato, Yuya Urano, Kanako C. Hatanaka, , Masahiro Sonoshita
This study shows that targeting the AMPK-MAPK axis in cancer-associated fibroblasts suppresses PDAC growth in fly and mouse models by restoring AMPK activity and inhibiting fibroblast activation.
bioRxiv · Mar 18, 2026 · PreprintCancer Biology