Wnt binding to Coatomer proteins directs secretion on exosomes independently of palmitoylation
Uxía Gurriarán‐Rodríguez, David Datzkiw, Leandro Radusky, Marie E. Esper, Ehsan Javandoost, Fan Xiao, Ming Hong, Solomon Fisher, Alberto Marina, Yves De Repentigny, Rashmi Kothary, Mikel Azkargorta, Félix Elortza, Adriana Lucely Rojas, Luis G. Serrano, , Michael A. Rudnicki
This study identifies the structural mechanism by which Wnt7a binds to exosomes for secretion, showing it is independent of palmitoylation and involves a dilysine motif interacting with COPB2.
Science Advances · Dec 11, 2024Peer-reviewedMolecular Biology