Choline Kinase Alpha Inhibition is a Mutation Agnostic Therapeutic Vulnerability in Clonal Hematopoiesis
Brandon J.F. Gheller, Olivia Mitchell, Michael Quach, Jayakrishnan Gopakumar, Serine Avagyan, Song Yang, Thomas P. Mathews, Chuck Haggerty, Alexander Meissner, Jacqueline García, Ralph J. DeBerardinis, Siddhartha Jaiswal, Fernando D. Camargo, Leonard Ira Zon
This study identifies CHKA/PAF metabolic dependency in clonal hematopoiesis across multiple mutations and shows its suppression reduces clonal expansion.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology