A novel 18F-labeled brain penetrant PET ligand for imaging poly(ADP-ribose) polymerase-1
Jimmy S. Patel, Xin Mu Zhou, Jiahui Chen, Yabiao Gao, Chunyu Zhao, Zhendong Song, Taoqian Zhao, Qi-Long Hu, Xiaoyan Li, Chongjiao Li, Songyu Wu, David M. Schuster, Lily P H Yang, Yinlong Li, David S. Yu, Steven H. Liang
This paper evaluates [18F]AZD9574, a PET radiotracer for imaging PARP-1, showing uptake correlated with PARP-1 expression and blocked by PARP inhibitors in cancer cell lines and xenograft models.
bioRxiv · Nov 1, 2025 · PreprintCancer Biology