Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut
Kouki K. Touhara, Nathan D. Rossen, Fei Deng, Joel Castro, Andrea M. Harrington, Tifany Chu, Sonia Garcia-Caraballo, Mariana Brizuela, Tracey O’Donnell, Jinhao Xu, Onur Cil, Stuart M. Brierley, Yulong Li, David Julius
This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.
bioRxiv · Feb 6, 2024Physiology