Author

Sonja N. Brun

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Allison S. LimpertiD· 3 shared Dhanya R. Panickar· 3 shared Douglas J. SheffleriD· 3 shared Fabiana Izidro LayngiD· 3 shared Nicholas D. P. CosfordiD· 3 shared Reuben J. ShawiD· 3 shared Huiyu ReniD· 2 shared Lester J. LambertiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Allison S. LimpertORCID

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Author profile →

3 papers

Recent·Most cited

Synthesis and Characterization of ULK1/2 Kinase Inhibitors that Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer

Fabiana Izidro Layng, Huiyu Ren, Nicole A. Bakas, Dhanya R. Panickar, Lester J. Lambert, Maria Celeridad, Jiaqian Wu, Laurent J. S. De Backer, Preeti Chandrachud, Allison S. Limpert, Mitchell Vamos, A. Chaikuad, Betsaida Bibo‐Verdugo, Patrick M. Hagan, Sonja N. Brun, , Nicholas D. P. Cosford

The paper reports the design, synthesis, and characterization of new ULK1/2 inhibitors that inhibit autophagy and upregulate MHC I in NSCLC cells, supporting their potential as cancer therapeutics.

ACS Chemical Biology · Feb 12, 2026Peer-reviewedCancer Biology

ULK1/2 Inhibitors that Degrade ATG13 Effectively Target KRAS-Mutant Cancers

Patrick M. Hagan, Huiyu Ren, Sonja N. Brun, Fabiana Izidro Layng, Dhanya R. Panickar, Lester J. Lambert, Maria Celeridad, Ranajit Das, Ling Li, Yijuan Zhang, Allison S. Limpert, Douglas J. Sheffler, Cosimo Commisso, Reuben J. Shaw, Nicholas D. P. Cosford

The paper identifies SBP-1750, a ULK inhibitor that degrades ATG13 and kills KRAS-mutant cancer cells, showing efficacy in vivo and immune enhancement.

bioRxiv · Oct 14, 2025 · PreprintCancer Biology

Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer

Suzanne Dufresne, Ramya S. Kuna, Kristiana Wong, Anvita Komarla, Louis R. Parham, Celina Shen, Payel Mondal, Adelaida Estrada-Cardenas, Angelica E. Rock, Joel Encarnación-Rosado, Amanda Cyril, Ginevra Doglioni, Dhanya R. Panickar, Nicole A. Bakas, Douglas J. Sheffler, , Christina G. Towers

This study identifies metabolic adaptations in pancreatic cancer cells resistant to autophagy inhibitors and shows that targeting pyrimidine salvage can enhance treatment efficacy.

bioRxiv · May 29, 2025 · PreprintCancer Biology