Novel, non-nitrocatechol COMT inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility
Spencer Byers, Ingrid P. Buchler, Michael J. Depasquale, Helen L. Rowley, Rajiv S. Kulkarni, Lucy Pinder, Anna Kolobova, Cailian Li, Vinh Au, Daniel Akuma, Gongliang Zhang, Huijun Wei, Sharon C. Cheetham, James C. Barrow, Gregory V. Carr
The paper identifies novel COMT inhibitors that improve cognitive flexibility in rats by modulating dopamine metabolites in the frontal cortex and cerebrospinal fluid.
Psychopharmacology · May 30, 2020Peer-reviewedNeuroscience