Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease
Min Joo Kim, Jessica R. Blumenfeld, Yaqiao Li, Oscar Yip, Leon Yao, Stephanie Ancheta, Samuel De Leon, Zoe Platow, Zherui Liang, David M. Shostak, Kaylie Suan, Yanxia Hao, Nicole Koutsodendris, Claire Ellis, Jeremy Nguyen, Yadong Huang
This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.
bioRxiv · Dec 9, 2025 · PreprintNeuroscience