Caspase-Activated DNase Localizes to Cancer Causing Translocation Breakpoints During Cell Differentiation
Dalal Alsowaida, Brian Daniel Larsen, Sarah Hachmer, Mehri Azimi, Eric Arezza, Steve Brunette, Steven Tur, Carmen G. Palii, Bassam Albraidy, Claus Storgaard Sørensen, Marjorie Brand, Francis Jeffrey Dilworth, Lynn A. Megeney
The paper identifies CAD-bound genes involved in both muscle cell differentiation and cancer-causing translocations, showing CAD-induced breaks are physiologic in differentiation and linked to oncogenic gene regulation.
bioRxiv · Sep 24, 2024 · PreprintGenomics