Author

Lynn A. Megeney

University of OttawaORCID 0000-0002-6824-8569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Francis Jeffrey DilworthiD· 3 shared Dalal AlsowaidaiD· 2 shared Eric ArezzaiD· 2 shared Sarah HachmeriD· 2 shared Steve Brunette· 2 shared Alphonse ChuiD· 1 shared Bassam AlbraidyiD· 1 shared Brian Daniel LarseniD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Francis Jeffrey DilworthORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Caspase-Activated DNase Localizes to Cancer Causing Translocation Breakpoints During Cell Differentiation

Dalal Alsowaida, Brian Daniel Larsen, Sarah Hachmer, Mehri Azimi, Eric Arezza, Steve Brunette, Steven Tur, Carmen G. Palii, Bassam Albraidy, Claus Storgaard Sørensen, Marjorie Brand, Francis Jeffrey Dilworth, Lynn A. Megeney

The paper identifies CAD-bound genes involved in both muscle cell differentiation and cancer-causing translocations, showing CAD-induced breaks are physiologic in differentiation and linked to oncogenic gene regulation.

bioRxiv · Sep 24, 2024 · PreprintGenomics

SMCHD1 activates the expression of genes required for the expansion of human myoblasts

Matthew Man-Kin Wong, Sarah Hachmer, Ed Gardner, Valeria Runfola, Eric Arezza, Lynn A Megeney, Charles P Emerson, Davide Gabellini, F Jeffrey Dilworth

This study shows SMCHD1 activates cell cycle genes in human myoblasts, promoting proliferation independently of DUX4, and identifies LAP2 as a key target gene.

bioRxiv · Feb 4, 2024Cell Biology

Chromatin reorganization during myoblast differentiation involves the caspase-dependent removal of SATB2

Ryan A. V. Bell, Mohammad H Al-Khalaf, Steve Brunette, Dalal Alsowaida, Alphonse Chu, Hina Bandukwala, Georg Dechant, Galina Apostolova, Francis Jeffrey Dilworth, Lynn A. Megeney

This study shows that SATB2 removal, mediated by caspase 7 cleavage, is critical for chromatin reorganization during myoblast differentiation.

Cells · Mar 11, 2022Peer-reviewedMolecular Biology