Distinct sub-cellular autophagy impairments occur independently of protein aggregation in induced neurons from patients with Huntington's disease
Karolina Pircs, Janelle Drouin‐Ouellet, Jeovanis Gil, Melinda Rezeli, Daniela A. Grassi, Raquel Garza, Yogita Sharma, Isabelle St‐Amour, Marie E. Jönsson, Pia Annette Johansson, Kate L. Harris, Romina Vuono, Thomas B. Stoker, Bob A. Hersbach, Kritika Sharma, , Johan Jakobsson
This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.
bioRxiv · Mar 1, 2021 · PreprintNeuroscience