Romina Vuono

Tau oligomers can occur in human brains within days of a single traumatic brain injury

This study identifies tau oligomers in the brains of individuals who died shortly after traumatic brain injury, suggesting an early pathological mechanism linked to Alzheimer's disease.

Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson's disease

This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.

Distinct sub-cellular autophagy impairments occur independently of protein aggregation in induced neurons from patients with Huntington's disease

This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.