CNS-penetrant NLRP3 inhibitor achieves durable weight loss and reverses hypothalamic inflammation in diet-induced obesity
Jing Guo, Tomás P. Bachor, Ryan Takahashi, Micah Steffek, Gabriel A. Fitzgerald, Benjamin J. Huffman, Dylan Braun, Suk Ji Han, Thomas Sandmann, Connie Ha, Katrina W. Lexa, Yun-Ting Hsieh, Maayan R. Agam, Elizabeth Wen Sun, Xiang Wang, , Ernie Yulyaningsih
TN-783, a CNS-penetrant NLRP3 inhibitor, induces sustained weight loss and reverses hypothalamic inflammation in diet-induced obese mice.
bioRxiv · Oct 6, 2025 · PreprintNeuroscience