Srimonta Gayen

Evolutionary origins and chromatin state shape X-chromosome upregulation pattern during eutherian and metatherian embryogenesis

The paper investigates how evolutionary origins and chromatin states influence X-chromosome upregulation patterns in eutherian and metatherian embryogenesis.

The role of m6A RNA methylation in the maintenance of X-chromosome inactivation and X to autosome dosage compensation in early embryonic lineages

This study investigates the role of m6A RNA methylation in X-chromosome inactivation and X to autosome dosage compensation in early embryonic lineages, finding that m6A depletion has a minor effect on dosage compensation.

Deletion of Xist upstream sequences alters TAD interactions and leads to defects in Xist coating and expression

The paper shows that deleting Xist upstream sequences disrupts TAD organization, affects Xist expression, and leads to dysregulation of autosomal genes.

Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation

The paper investigates lineage-specific coordination of X-chromosome inactivation and active-X upregulation in female cells across different developmental contexts and identifies UTF1 as a mediator of X-upregulation erasure in some lineages.

Single-cell allelic transcriptomic analysis unravels intratumoral gene expression heterogeneity linked to TNBC pathogenesis

This study uses single-cell RNA-sequencing to analyze allelic expression heterogeneity in TNBC, linking it to immune-surveillance and drug-resistance pathways.

Gestational exposure to high heat-humidity conditions impairs mouse embryonic development

This study establishes a mouse model of heat-humidity stress during pregnancy and shows its cumulative teratogenic effects on embryonic development, leading to higher embryonic deaths and malformations.

Chromatin states contribute to coordinated allelic transcriptional bursting to drive iPSC reprogramming

The paper investigates how chromatin states influence coordinated allelic transcriptional bursting during iPSC reprogramming and finds that chromatin accessibility correlates with allelic coordination.

Gene-specific reactivation of X-linked genes upon Xist loss is linked to the chromatin states in extraembryonic endoderm and epiblast stem cells

The paper investigates how Xist loss affects X-linked gene reactivation in XEN and EpiSC, showing that chromatin states determine gene silencing stability.

X upregulation is not global and extent of upregulation differs between ancestral and acquired X-linked genes

The paper investigates X-chromosome upregulation (XCU) in mouse embryos and finds it is not global, differs between ancestral and acquired X-linked genes, and may not drive the evolution of X-chromosome inactivation (XCI).

Semi-coordinated allelic-bursting shape dynamic random monoallelic expression in pregastrulationembryos

The paper investigates dynamic random monoallelic expression (aRME) in pre-gastrulation embryos, finding that allelic bursting is semi-coordinated rather than independent, leading to expression heterogeneity.

Single Cell Analysis Reveals Partial Reactivation of X-chromosome Instead of chromosome-wide dampening in Naïve Human Pluripotent Stem Cells

The paper uses single-cell analysis to show partial reactivation of the inactive X-chromosome in naive human pluripotent stem cells, challenging the notion of chromosome-wide dampening.

Ligand dependent gene regulation by transient ERα clustered enhancers

The paper shows that unliganded ERα pre-marks enhancer sites, which form 3D clusters upon ligand exposure, driving transient gene expression.

Induction of X-chromosome Inactivation by the Histone Demethylase SMCX/KDM5C

This study shows that SMCX/KDM5C, a histone demethylase, is required for X-inactivation in female mammals by inducing Xist RNA and silencing X-linked genes.