Deepshikha Chandel

Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation

The paper investigates lineage-specific coordination of X-chromosome inactivation and active-X upregulation in female cells across different developmental contexts and identifies UTF1 as a mediator of X-upregulation erasure in some lineages.

X upregulation is not global and extent of upregulation differs between ancestral and acquired X-linked genes

The paper investigates X-chromosome upregulation (XCU) in mouse embryos and finds it is not global, differs between ancestral and acquired X-linked genes, and may not drive the evolution of X-chromosome inactivation (XCI).

Semi-coordinated allelic-bursting shape dynamic random monoallelic expression in pregastrulationembryos

The paper investigates dynamic random monoallelic expression (aRME) in pre-gastrulation embryos, finding that allelic bursting is semi-coordinated rather than independent, leading to expression heterogeneity.

Single Cell Analysis Reveals Partial Reactivation of X-chromosome Instead of chromosome-wide dampening in Naïve Human Pluripotent Stem Cells

The paper uses single-cell analysis to show partial reactivation of the inactive X-chromosome in naive human pluripotent stem cells, challenging the notion of chromosome-wide dampening.