Hemant Chandru Naik

The paper investigates how evolutionary origins and chromatin states influence X-chromosome upregulation patterns in eutherian and metatherian embryogenesis.

This study investigates the role of m6A RNA methylation in X-chromosome inactivation and X to autosome dosage compensation in early embryonic lineages, finding that m6A depletion has a minor effect on dosage compensation.

The paper shows that deleting Xist upstream sequences disrupts TAD organization, affects Xist expression, and leads to dysregulation of autosomal genes.

The paper investigates lineage-specific coordination of X-chromosome inactivation and active-X upregulation in female cells across different developmental contexts and identifies UTF1 as a mediator of X-upregulation erasure in some lineages.

This study uses single-cell RNA-sequencing to analyze allelic expression heterogeneity in TNBC, linking it to immune-surveillance and drug-resistance pathways.

The paper investigates how chromatin states influence coordinated allelic transcriptional bursting during iPSC reprogramming and finds that chromatin accessibility correlates with allelic coordination.

The paper investigates X-chromosome upregulation (XCU) in mouse embryos and finds it is not global, differs between ancestral and acquired X-linked genes, and may not drive the evolution of X-chromosome inactivation (XCI).

The paper investigates dynamic random monoallelic expression (aRME) in pre-gastrulation embryos, finding that allelic bursting is semi-coordinated rather than independent, leading to expression heterogeneity.