Sudeshna Majumdar

Deletion of Xist upstream sequences alters TAD interactions and leads to defects in Xist coating and expression

The paper shows that deleting Xist upstream sequences disrupts TAD organization, affects Xist expression, and leads to dysregulation of autosomal genes.

Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation

The paper investigates lineage-specific coordination of X-chromosome inactivation and active-X upregulation in female cells across different developmental contexts and identifies UTF1 as a mediator of X-upregulation erasure in some lineages.

Single Cell Analysis Reveals Partial Reactivation of X-chromosome Instead of chromosome-wide dampening in Naïve Human Pluripotent Stem Cells

The paper uses single-cell analysis to show partial reactivation of the inactive X-chromosome in naive human pluripotent stem cells, challenging the notion of chromosome-wide dampening.