Tether-mediated extraction of myelinoid bodies by microglia and astrocytes can maintain myelin integrity
Erik Späte, Kieran P. Higgins, Yeonsu Kim, Carolina Mangana, Lina Komarek, Mohammadhossein Teymouri, Ulrike C. Gerwig, Svea Melzer, Boguslawa Sadowski, Torben Ruhwedel, Predrag Janjić, Bastiaan Lodder, Andrew J. Dwork, Maarten H. P. Kole, Anna M. Steyer, , Sandra Goebbels
The paper shows that microglia and astrocytes extract myelinoid bodies via tethers, preserving myelin sheath integrity through tension-driven scission and fusion.
bioRxiv · Dec 9, 2025 · PreprintNeuroscience