Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain
Nisha Hemandhar-Kumar, Verena Kluever, Svenja V. Kaufmann, Cornelius Bergmann, Kanaan Mousaei, Miguel Tomas, Miguel Correa Marrero, Avika Chopra, Misa Hirose, Mercè Pallàs, Coral Sanfeliu, Saleh Mohamed Ibrahim, André Fischer, Tiago F. Outeiro, Henning Urlaub, , Eugenio F. Fornasiero
This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.
bioRxiv · Aug 14, 2025 · PreprintNeuroscience