Discovery of metabolites produced by reactions between central carbon metabolites and cysteine that mark inflammatory macrophages
Nicholas L. Arp, Felicia Deng, Jorgo Lika, Gretchen L. Seim, Paulo Falco Cobra, Carlos Mellado Fritz, Steven V John, Swetha Rathinaraj, Bridget E. Shields, Daniel Amador‐Noguez, Katherine A. Henzler‐Wildman, Jing Fan
The paper identifies sulfur-containing metabolites specific to inflammatory macrophages, showing they are produced from cysteine and central metabolism intermediates and are elevated in human inflammatory lesions.
bioRxiv · Mar 20, 2026 · PreprintBiochemistry