Author

Symen Ligthart

Erasmus MC

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 2 Genomics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:statistical model· 4 Research Focus:fine-mapping· 3 Assay:GWAS summary statistics· 3 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Audrey Y. ChuiD· 3 shared Ayşe DemirkaniD· 3 shared Jun LiuiD· 3 shared Lawrence F. BielakiD· 3 shared Michael H PreussiD· 3 shared Abbas DehghaniD· 2 shared Allan R LinnebergiD· 2 shared Anubha MahajaniD· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetics

Audrey Y. ChuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

Ji Chen, Cassandra Nichole Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J. Corbin, Jian’an Luan, Sara M. Willems, Ying Wu, Xiaoshuai Zhang, Momoko Horikoshi, Thibaud Boutin, Reedik Mägi, Johannes Waage, Achilleas Pitsillides, Ruifang Li‐Gao, , Michael H Preuss

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

bioRxiv · Jul 23, 2020 · PreprintGenetics

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

Jun Liu, Elena Carnero‐Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning W. Tiemeier, Janine F. Felix, , Cornelia M. van Duijn

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

Nature Communications · Jun 13, 2019Peer-reviewedGenomics

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, Audrey Y. Chu, Wei Gan, Hidetoshi Kitajima, Daniel Taliun, Nigel William Rayner, Xiuqing Guo, Yingchang Lu, Man Li, Richard A. Jensen, Yao Hu, , Jun Liu

This study identifies 16 causal coding variants in type 2 diabetes using fine-mapping and shows that one third of signals are false leads.

Nature Genetics · Apr 1, 2018Peer-reviewedGenetics

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason Torres, Nigel William Rayner, Valgerður Steinthórsdóttir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, , Claudia Langenberg

This study fine-maps type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps, identifying 73 variants with >80% posterior probability of association.

bioRxiv · Jan 9, 2018 · PreprintGenomics