Author

T. A. Ficht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. de Figueiredo· 4 shared Q.-M. Qin· 3 shared A. Pandey· 2 shared A. Rice-Ficht· 2 shared G. Gomez· 2 shared J. Yang· 2 shared K. L. PatrickiD· 2 shared L. F. da Costa· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersMicrobiology

P. de Figueiredo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A metabolically engineered bacterium controls autoimmunity by remodeling the pro-inflammatory microenvironment

J. K. Das, F. Guo, C. Hunt, S. Steinmeyer, J. A. Plocica, K. S. Kobayashi, A. Jayaraman, T. A. Ficht, R. C. Alaniz, P. de Figueiredo, J. Song

A metabolically engineered bacterium produces indole to modulate macrophages and Tregs, reducing autoimmune arthritis by altering the pro-inflammatory microenvironment.

bioRxiv · Feb 26, 2022 · PreprintImmunology

Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense

K. M. Wells, K. He, A. Pandey, A. Cabello, D. Zhang, J. Yang, G. Gomez, Y. Liu, H. Chang, X. Li, H. Zhang, L. F. da Costa, R. Metz, C. D. Johnson, C. L. Martin, , P. de Figueiredo

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

bioRxiv · Nov 4, 2021Microbiology

Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes

S. Ding, A. Pandey, X. Feng, J. Yang, L. F. da Costa, R. B. Mouneimne, A. Rice-Ficht, S. L. Bell, R. O. Watson, K. L. Patrick, Q.-M. Qin, T. A. Ficht, P. de Figueiredo

This paper shows fungal hyaluronic acid interacts with host CD44 to recruit autophagy proteins to phagosomes, promoting fungal internalization via a Ca2+ -CaMKKβ-AMPK-ULK1 signaling pathway.

iScience · Mar 1, 2021Peer-reviewedMicrobiology

A tractable Drosophila cell system enables rapid identification of Acinetobacter baumannii host factors

Q.-M. Qin, J. Pei, G. Gomez, A. Rice-Ficht, T. A. Ficht, P. de Figueiredo

This study uses Drosophila S2 cells to identify host factors and mechanisms involved in Acinetobacter baumannii intracellular survival and persistence.

bioRxiv · Apr 9, 2020Microbiology