A metabolically engineered bacterium controls autoimmunity by remodeling the pro-inflammatory microenvironment
J. K. Das, F. Guo, C. Hunt, S. Steinmeyer, J. A. Plocica, K. S. Kobayashi, A. Jayaraman, T. A. Ficht, R. C. Alaniz, P. de Figueiredo, J. Song
A metabolically engineered bacterium produces indole to modulate macrophages and Tregs, reducing autoimmune arthritis by altering the pro-inflammatory microenvironment.
bioRxiv · Feb 26, 2022 · PreprintImmunology