Author

T. A. Hacker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Zhang· 2 shared A. C. Rodgers· 1 shared A. N. Raval· 1 shared C. Koonce· 1 shared C. L. Green· 1 shared C. U. Braz· 1 shared C.-Y. Yeh· 1 shared D. Lamming· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPathology

J. Zhang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias

A. N. Raval, E. G. Schmuck, V. Leonov, S. Roy, Y. Saito, T. Zhou, H. J. Jang, K. Wilker, J. Conklin, T. A. Hacker, C. Koonce, M. Boyer, K. Stack, E. Hebron, S. K. Nagle, , T. J. Kamp

The paper demonstrates that hiPSC-derived cardiac progenitor cells injected into swine hearts after MI form grafts that improve stress-induced contractile reserve without causing arrhythmias.

bioRxiv · Feb 14, 2024 · PreprintPathology

Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging

C.-Y. Yeh, L. C. S. Chini, J. W. Davidson, G. G. Garcia, M. S. Gallagher, I. T. Freichels, M. F. Calubag, A. C. Rodgers, C. L. Green, R. Babygirija, M. M. Sonsalla, H. H. Pak, M. Trautman, T. A. Hacker, R. A. Miller, , D. Lamming

This study shows that reducing amino acids or isoleucine in the diet of aged mice improves metabolic health, reduces frailty, and slows aging markers.

bioRxiv · Feb 6, 2023 · PreprintPhysiology

Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy

Y. Zhang, Z. R. Gregorich, Y. Wang, C. U. Braz, J. Zhang, Y. Liu, P. Liu, N. Aori, T. A. Hacker, H. Granzier, W. Guo

This study identifies disruption of the nuclear localization signal in RBM20 as a causative mechanism in dilated cardiomyopathy through impaired nucleocytoplasmic transport.

bioRxiv · Dec 8, 2022Cell Biology