Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging
C.-Y. Yeh, L. C. S. Chini, J. W. Davidson, G. G. Garcia, M. S. Gallagher, I. T. Freichels, M. F. Calubag, A. C. Rodgers, C. L. Green, R. Babygirija, M. M. Sonsalla, H. H. Pak, M. Trautman, T. A. Hacker, R. A. Miller, , D. Lamming
This study shows that reducing amino acids or isoleucine in the diet of aged mice improves metabolic health, reduces frailty, and slows aging markers.
bioRxiv · Feb 6, 2023 · PreprintPhysiology