Author

H. H. Pak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4

Signature Assays, Organisms & Methods

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Assay:metabolomics· 4 Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. L. Green· 4 shared R. Babygirija· 4 shared C.-Y. Yeh· 3 shared D. Lamming· 3 shared M. F. Calubag· 3 shared M. M. Sonsalla· 3 shared J. Simcox· 2 shared A. Bleicher· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersPhysiology

C. L. Green

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4 papers

Recent·Most cited

Non-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

H. H. Pak, A. N. Grossberg, R. R. Sanderfoot, R. Babygirija, C. L. Green, M. J. Koller, M. Dzieciatkowska, D. A. Paredes, D. W. Lamming

This study reveals that calorie restriction's effects on metabolism and molecular processes depend on the timing of measurements relative to feeding, not just diet alone.

bioRxiv · Feb 15, 2024Physiology

Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging

C.-Y. Yeh, L. C. S. Chini, J. W. Davidson, G. G. Garcia, M. S. Gallagher, I. T. Freichels, M. F. Calubag, A. C. Rodgers, C. L. Green, R. Babygirija, M. M. Sonsalla, H. H. Pak, M. Trautman, T. A. Hacker, R. A. Miller, , D. Lamming

This study shows that reducing amino acids or isoleucine in the diet of aged mice improves metabolic health, reduces frailty, and slows aging markers.

bioRxiv · Feb 6, 2023 · PreprintPhysiology

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

C. L. Green, M. E. Trautman, R. Babygirija, R. Jain, K. Chaiyakul, H. H. Pak, A. Bleicher, G. Novak, M. M. Sonsalla, C.-Y. Yeh, M. F. Calubag, T. T. Liu, V. Flores, S. Newman, W. A. Ricke, , D. Lamming

This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.

bioRxiv · Oct 6, 2022Physiology

FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice

M. F. Calubag, I. Ademi, C.-Y. Yeh, R. Babygirija, A. M. Bhoopat, I. Kasza, M. M. Sonsalla, C. L. Green, H. H. Pak, D. Lamming

This study investigates the role of FGF21 in calorie-restricted diet-induced metabolic changes in mice, finding it dispensable for most effects but sex-specific in adipose tissue beiging.

bioRxiv · Jul 29, 2022Physiology