Author

T. Alenghat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:metagenomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

E. M. Eshleman· 3 shared L. Engleman· 3 shared T. Rice· 3 shared V. Woo· 3 shared J. Whitt· 2 shared S. Hashimoto-Hill· 2 shared S. S. Way· 2 shared T.-y. Shao· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

E. M. Eshleman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns

J. Stevens, E. Culberson, J. Kinder, A. R. Ramiriqui, J. Gray, M. Bonfield, T.-y. Shao, F. Al Gharabieh, L. Peterson, S. Steinmeyer, W. J. Zacharias, G. Pryhuber, O. Paul, S. Sengupta, T. Alenghat, , H. Deshmukh

This study identifies microbiota-derived inosine as a key factor in promoting CD8+ T cell responses against influenza in newborns by reversing epigenetic dysregulation.

bioRxiv · Apr 9, 2024Immunology

Microbiota epigenetically direct tuft cell differentiation to control type 2 immunity

E. M. Eshleman, T. Rice, C. Potter, A. Waddell, S. Hashimoto-Hill, V. Woo, S. Field, L. Engleman, M. A. Schumacher, M. R. Frey, L. A. Denson, F. D. Finkelman, T. Alenghat

This study shows that butyrate-producing bacteria epigenetically control tuft cell differentiation via HDAC3, influencing type 2 immunity and helminth responses.

bioRxiv · Mar 2, 2023Immunology

Intestinal epithelial MHC class II regulation by HDAC3 instructs microbiota-specific CD4+ T cells

E. M. Eshleman, T.-Y. Shao, V. Woo, T. Rice, J. Whitt, L. Engleman, S. S. Way, T. Alenghat

This study shows that epithelial HDAC3 regulates MHCII expression, which limits commensal-specific Th17 cells and prevents microbiota-triggered inflammation.

bioRxiv · Jan 1, 2022Immunology

Commensal bacterial-derived retinoic acid primes host defense to intestinal infection

T. Alenghat, V. Woo, E. M. Eshleman, J. Whitt, S. Hashimoto-Hill, S.-e. Wu, L. Engleman, T. Rice, R. Karns, B. A. Vallance

This study identifies retinoic acid (RA) as a microbiota-derived metabolite that enhances intestinal defense against infection by modulating host gene expression.

bioRxiv · Jan 27, 2021Microbiology