Microbiota epigenetically direct tuft cell differentiation to control type 2 immunity
E. M. Eshleman, T. Rice, C. Potter, A. Waddell, S. Hashimoto-Hill, V. Woo, S. Field, L. Engleman, M. A. Schumacher, M. R. Frey, L. A. Denson, F. D. Finkelman, T. Alenghat
This study shows that butyrate-producing bacteria epigenetically control tuft cell differentiation via HDAC3, influencing type 2 immunity and helminth responses.
bioRxiv · Mar 2, 2023Immunology