MicrobiologybioRxivPreprint
A genome-wide loss-of-function screen identifies Toxoplasma gondii genes that determine fitness in interferon gamma-activated murine macrophages
Y. Wang, L. O. Sangare, T. C. Paredes-Santos…·J. P. J. Saeij
The paper uses a genome-wide CRISPR screen to identify Toxoplasma gondii genes critical for fitness in IFN-gamma-activated murine macrophages, with GRA45 shown to prevent effector aggregation and enhance parasite survival.
DOI 10.1101/867705