Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
17 papers
Recent·Most cited
P. Thaprawat, Z. Zhang, E. C. Rentchler, F. Wang, S. Chalasani, C. J. Giuliano, S. Lourido, M. Di Cristina, D. J. Klionsky, V. B. Carruthers
This study identifies TgATG9 as essential for autophagosome formation and chronic Toxoplasma gondii infection.
bioRxiv · Jul 8, 2024 · PreprintMicrobiology
L. A. Shallberg, J. N. Eberhard, A. Winn, S. Chandrasekaran, C. J. Giuliano, E. F. Merritt, E. Willis, D. A. Christian, D. L. Aldridge, M. Bunkofske, M. Jacquet, F. Dzierszinski, E. Katifori, S. Lourido, A. A. Koshy, C. A. Hunter
This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.
bioRxiv · Mar 5, 2024 · PreprintMicrobiology
F. Wang, M. J. Holmes, H. J. Hong, P. Thaprawat, G. Kannan, M.-H. Huynh, T. L. Schultz, M. H. Licon, S. Lourido, W. Dong, J. Brito Querido, W. J. Sullivan, S. E. O Leary, V. B. Carruthers
This study identifies eIF1.2 as a regulator of Toxoplasma gondii differentiation by controlling the translation of key bradyzoite factors.
bioRxiv · Nov 3, 2023 · PreprintMicrobiology
C. J. Giuliano, K. J. Wei, F. M. Harling, B. S. Waldman, M. A. Farringer, E. A. Boydston, T. C. T. Lan, R. W. Thomas, A. L. Herneisen, A. G. Sanderlin, I. Coppens, J. D. Dvorin, S. Lourido
The paper uses CRISPR screens to identify 300+ genes in Toxoplasma gondii that affect parasite fitness in mice, revealing new roles in host-parasite interactions and potential drug targets.
bioRxiv · Mar 5, 2023 · PreprintMicrobiology
A. W. Chan, M. Broncel, E. Yifrach, N. R. Haseley, S. Chakladar, E. Andree, A. L. Herneisen, E. Shortt, M. Treeck, S. Lourido
This study identifies CDPK1 targets in Toxoplasma gondii, revealing a trafficking adaptor complex that regulates microneme exocytosis and host cell invasion.
bioRxiv · Jan 11, 2023 · PreprintMicrobiology
S. Sidik, D. Valleau, Y. Acevedo-Sanchez, L. C. Godoy, C. F. A. Pasaje, M.-H. Huynh, V. B. Carruthers, J. C. Niles, S. Lourido
The paper identifies a conserved microneme protein complex, CLAMP-SPATR-CLIP, essential for rhoptry discharge in Toxoplasma gondii.
bioRxiv · Nov 28, 2022 · PreprintMicrobiology
E. Shortt, C. G. Hackett, R. V. Stadler, G. E. WARD, S. Lourido
This paper identifies CDPK2A and CDPK1 as a signaling module regulating Toxoplasma motility, showing their functional interaction and role in microneme discharge and egress.
bioRxiv · Jul 19, 2022 · PreprintMicrobiology
A. L. Herneisen, Z.-H. Li, A. W. Chan, S. N. Moreno, S. Lourido
The paper maps the Ca2+-responsive proteome of T. gondii using phosphoproteomics and thermal proteome profiling, identifying both known and novel proteins involved in Ca2+ signaling pathways.
bioRxiv · May 25, 2022 · PreprintMicrobiology
M. H. Licon, C. J. Giuliano, S. Chakladar, L. Shallberg, B. S. Waldman, C. A. Hunter, S. Lourido
The paper identifies a positive feedback loop between BFD1 and BFD2 that drives Toxoplasma gondii chronic differentiation.
bioRxiv · Apr 6, 2022Microbiology
T. A. Smith, G. S. Lopez-Perez, E. Shortt, S. Lourido
This study uses a high-throughput CRISPR system to functionally analyze the Toxoplasma kinome, identifying SPARK as a novel regulator of invasion and egress.
bioRxiv · Sep 23, 2021 · PreprintMicrobiology
Y. Rivera-Cuevas, J. Mayoral, M. Di Cristina, A.-L. E. Lawrence, E. B. Olafsson, D. Thornhill, B. S. Waldman, A. Ono, J. Sexton, S. Lourido, L. M. Weiss, V. B. Carruthers
This study identifies TgGRA14 as a parasite protein that recruits the host ESCRT machinery to facilitate uptake of host cytosolic proteins across the parasitophorous vacuole membrane.
bioRxiv · Jul 21, 2021Microbiology
G. J. Ray, E. A. Boydston, E. Shortt, G. A. Wyant, S. Lourido, W. W. Chen, D. M. Sabatini
This paper introduces a PEROXO-Tag and PEROXO-IP workflow for rapid and specific isolation of human peroxisomes, validated through proteomic profiling.
iScience · May 1, 2020Peer-reviewedCell Biology
Y. Wang, L. O. Sangare, T. C. Paredes-Santos, S. Krishnamurthy, M. A. Hassan, A. M. Furuta, B. M. Markus, S. Lourido, J. P. J. Saeij
The paper uses a genome-wide CRISPR screen to identify Toxoplasma gondii genes critical for fitness in IFN-gamma-activated murine macrophages, with GRA45 shown to prevent effector aggregation and enhance parasite survival.
bioRxiv · Dec 6, 2019 · PreprintMicrobiology
C. Harding, S. M. Sidik, B. Petrova, N. F. Gnädig, J. Okombo, K. E. Ward, B. M. Markus, D. A. Fidock, S. Lourido
The paper uses CRISPR screens to identify genetic factors affecting artemisinin susceptibility in apicomplexan parasites, revealing heme biosynthesis as a key pathway.
bioRxiv · Aug 28, 2019Microbiology
B. S. Waldman, D. Schwarz, M. H. Wadsworth, J. P. J. Saeij, A. K. Shalek, S. Lourido
This study identifies BFD1 as a master regulator of differentiation in Toxoplasma gondii through genetic screening and single-cell profiling, showing its necessity and sufficiency for the transition from tachyzoites to bradyzoites.
bioRxiv · Jun 5, 2019Microbiology
D. Huet, E. Rajendran, G. van Dooren, S. Lourido
The paper identifies 11 novel subunits of the Toxoplasma ATP synthase, including ICAP2 and ICAP18, which show distant homology to mammalian stator subunits and are essential for complex function.
bioRxiv · May 11, 2018Microbiology