Author
J. P. J. Saeij
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2019-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 17 mutual co-author links5 papers
Recent·Most cited
- MicrobiologybioRxivPreprint
GRA47 and GRA72 are Toxoplasma gondii pore-forming proteins that influence small molecule permeability of the parasitophorous vacuole
M. A. Bitew, P. S. Gaeteb, C. Swale…·J. P. J. Saeij
This paper identifies GRA47 and GRA72 as Toxoplasma gondii pore-forming proteins that regulate small molecule permeability of the parasitophorous vacuole, with mutations affecting their function and virulence.
DOI 10.1101/2023.11.15.567216 - ImmunologybioRxiv
Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5
A. K. Kongsomboonvech, F. Rodriguez, A. L. Diep…·K. Jensen
This study identifies NLRP3-dependent but inflammasome-independent pathways regulating CD8 T cell IFNγ responses to Toxoplasma gondii vacuolar antigens, independent of ROP5 virulence factors.
DOI 10.1371/journal.ppat.1008327 - MicrobiologybioRxivPreprint
A genome-wide loss-of-function screen identifies Toxoplasma gondii genes that determine fitness in interferon gamma-activated murine macrophages
Y. Wang, L. O. Sangare, T. C. Paredes-Santos…·J. P. J. Saeij
The paper uses a genome-wide CRISPR screen to identify Toxoplasma gondii genes critical for fitness in IFN-gamma-activated murine macrophages, with GRA45 shown to prevent effector aggregation and enhance parasite survival.
DOI 10.1101/867705 - MicrobiologybioRxiv
Identification of a master regulator of differentiation in Toxoplasma
B. S. Waldman, D. Schwarz, M. H. Wadsworth…·S. Lourido
This study identifies BFD1 as a master regulator of differentiation in Toxoplasma gondii through genetic screening and single-cell profiling, showing its necessity and sufficiency for the transition from tachyzoites to bradyzoites.
DOI 10.1016/j.cell.2019.12.013