Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases
A. A. Adhikari, T. C. Seegar, S. B. Ficarro, M. D. McCurry, D. Ramachandran, L. Yao, S. N. Chaudhari, S. Ndousse-Fetter, A. S. Banks, J. A. Marto, S. C. Blacklow, A. S. Devlin
This study develops a covalent inhibitor of gut bacterial bile salt hydrolases, showing it reduces BSH activity and deconjugated bile acids in mice.
bioRxiv · May 17, 2019Microbiology