R. I. Morimoto

Global proteome metastability response in isogenic animals to missense mutations and polyglutamine expansions in aging

This study examines how proteome conformational stability changes in aging C. elegans due to missense mutations and polyglutamine expansions, revealing age-dependent metastable protein networks.

Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism

This study quantitatively models protein aggregation in C. elegans using a molecular framework, showing that nucleation rates and stochasticity drive aggregation in vivo, consistent with in vitro findings.

Resetting proteostasis with ISRIB prevents pulmonary fibrosis

ISRIB reduces pulmonary fibrosis severity in young and old mice by modulating stress response signaling in alveolar epithelial cells.

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

This study examines proteome changes in alveolar macrophages and type 2 cells from young and old mice before and after influenza infection, revealing age-related proteostasis and mitochondrial dysfunction that worsen with infection.

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing

The paper develops a targeted RNA-seq assay to screen and deconvolute stress-responsive signaling pathway activation, demonstrating its utility for identifying selective pharmacologic activators.