S. Hannenhalli

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

Broad misappropriation of developmental splicing profile by cancer in multiple organs

The paper shows cancer reactivates embryonic splicing events, linking development and cancer through splicing factors and identifies potential therapeutic targets.

Cross-species identification of cancer-resistance associated genes uncovers their relevance to human cancer risk

The paper identifies cancer-resistance associated genes across species and finds their relevance to human cancer risk through conservation analysis and functional studies.

Single-cell profiling of tumor-reactive CD4+ T-cells reveals unexpected transcriptomic diversity

The paper uses single-cell RNA sequencing to reveal diverse transcriptomic patterns in CD4+ T cells responding to tumors, highlighting differences from virus responses and potential implications for immunotherapy.

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.