T. Cohen

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.

Elasticity of Whole Blood Clots Measured via Volume Controlled Cavity Expansion

This paper measures the mechanical properties of whole blood clots using Volume Controlled Cavity Expansion and finds that a 1-term Ogden model captures their nonlinear elasticity, with a significant decrease in shear modulus after 2 days of storage.

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes

Morphogenesis and cell ordering in confined bacterial biofilms

This study investigates how confined environments influence biofilm morphology and cell ordering in Vibrio cholerae using single-cell imaging and biomechanical analysis.

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

This study models how antibiotic mechanisms affect resistance mutation fitness, finding that drug type has little impact on resistance selection but that heterogeneous binding enables secondary mutations under certain conditions.

Drug-target binding quantitatively predicts optimal antibiotic dose levels

This paper develops a computational model to predict antibiotic dose-response relationships from drug-target binding parameters and validates it with clinical isolates.

Evaluation of tuberculosis treatment response with serial C-reactive protein measurements

This study evaluates CRP as a biomarker for tuberculosis treatment response, finding significant reductions in CRP and its predictive value for adverse outcomes.

Trends in CRP, D-dimer and fibrinogen during therapy for HIV associated multidrug resistant tuberculosis

This study tracks CRP, D-dimer, and fibrinogen levels in HIV-positive patients with MDR-TB to assess treatment response and mortality risk.