Author

T. D. Manz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

C. M. Browne· 2 shared H.-S. Seo· 2 shared J. A. Marto· 2 shared N. S. Gray· 2 shared S. B. Ficarro· 2 shared S. Dhe-Paganon· 2 shared A. Yang· 1 shared B. J. Pinch· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

C. M. Browne

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Author profile →

2 papers

Recent·Most cited

Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo

C. Dubiella, B. J. Pinch, D. Zaidman, T. D. Manz, E. Poon, S. He, E. Resnick, E. M. Langer, C. J. Daniel, H.-S. Seo, Y. Chen, S. B. Ficarro, Y. Jamin, X. Lian, S. Kibe, , N. London

Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.

bioRxiv · Mar 20, 2020 · PreprintCancer Biology

Targeting the PI5P4K lipid kinase family in cancer using novel covalent inhibitors

S. C. Sivakumaren, H. Shim, T. Zhang, F. M. Ferguson, M. R. Lundquist, C. M. Browne, H.-S. Seo, M. N. Paddock, T. D. Manz, B. Jiang, M.-F. Hao, P. Krishnan, D. G. Wang, T. J. Yang, N. P. Kwiatkowski, , N. S. Gray

This study identifies THZ-P1-2, a covalent pan-PI5P4K inhibitor, showing efficacy in AML/ALL cell lines and autophagy disruption, supporting PI5P4Ks as therapeutic targets in cancer.

bioRxiv · Oct 25, 2019Cancer Biology