T. D. Randall

HLA topography enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients

The paper identifies an immunodominant B cell response targeting specific HLA residues in transplant recipients, suggesting antigenic topography drives antibody-mediated rejection.

A high-throughput multiplex array for antigen-specific serology with automated analysis.

The paper describes a high-throughput CBA system for antigen-specific serology with automated analysis tools to quantify IgM, IgA, and IgG concentrations.

Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission

This study compares intranasal and intramuscular delivery of a self-amplifying RNA SARS-CoV-2 vaccine, showing that intranasal delivery induces mucosal immunity and reduces viral transmission.

Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE following helminth infection

This study shows that ChI3L1 is required for TH2, TFH, and IgE responses following helminth infection and vaccination, but not for IgG1 responses.

ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells

This study shows ICOS costimulation is essential for Tfr cell differentiation during GC reactions and highlights their role in immune tolerance.

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

The paper identifies T-bethi Bmem cells as predictors of long-lived antibody responses to influenza vaccination in humans.

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.