S. Roberts

Understanding and addressing under-sampling in plant-pollinator networks using stacked models for missing link prediction

This paper introduces a stacked model to predict missing links in under-sampled plant-pollinator networks using species traits and network topology, showing it can reconstruct networks and identify important features.

Long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin trafficking and secretion in mice

DNA methylation correlates with transcriptional noise in response to elevated pCO2 in the eastern oyster (Crassostrea virginica)

This study examines how DNA methylation and gene expression respond to elevated pCO2 in eastern oysters, finding sex-specific effects on transcriptional noise and gene regulation.

Phase-changing citrate macromolecule combats oxidative pancreatic islet damage, enables islet engraftment and function in the omentum

PPCN, a thermoresponsive antioxidant polymer, supports islet viability and function in nonhuman primates when used for omentum transplantation.

CyVerse: Cyberinfrastructure for Open Science

The paper describes CyVerse, an open-source cyberinfrastructure platform for life sciences, and outlines a strategic blueprint for managing SaaS and IaC as free and open-source software.

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic Organoids

This study uses human hepatic organoids to identify pro-fibrotic signaling pathways and potential therapies for liver fibrosis.

Preclinical shortwave infrared tumor screening and resection via pHLIP ICG under ambient lighting conditions

This study demonstrates that SWIR imaging with pHLIP ICG enables sensitive tumor detection and resection under ambient lighting conditions in a preclinical breast cancer model.

CSL-Tox: An open-source analytical framework for the comparison of short-term and long-term toxicity end points and exploring the opportunities for decreasing in-vivo studies conducted for drug development programs.

This study compares short-term and long-term toxicity findings to assess if short-term studies can predict long-term effects, supporting reduced in-vivo testing.

Variability in mosquito community composition associated with estuarine wetlands in Northern NSW, Australia

The paper examines mosquito community variability in estuarine wetlands, finding differences in species abundance and richness across four locations in Northern NSW, Australia.

Characterization of the gene repertoire and environmentally driven expression patterns in Tanner crab (Chionoecetes bairdi)

This study characterizes the gene repertoire and temperature-driven expression patterns in Tanner crab infected with Hematodinium, revealing insights into energy allocation and morphological changes under different thermal conditions.

The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expression

This paper shows CTCF regulates HPV18 transcript splicing and late gene expression during differentiation by controlling chromatin looping and splice site usage.

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

This study shows that chromosomal imbalances in hESCs provide a proliferative advantage under replicative stress, similar to cancer cells.

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

A Single Dose of Self-Transcribing and Replicating RNA Based SARS-CoV-2 Vaccine Produces Protective Adaptive Immunity In Mice

A single dose of the STARR-based SARS-CoV-2 vaccine LUNAR-COV19 induces protective adaptive immunity in mice, including strong antibody and CD8+ T cell responses, and full protection against viral challenge.

Latent effects of winter warming on Olympia oyster reproduction and larval viability

This study investigates how winter warming affects Olympia oyster reproduction and larval viability, finding that warmer winters lead to larger oocytes and larvae but do not impact larval survival or reproductive timing.

Optoacoustic imaging of GLP-1 Receptor with a near-infrared exendin-4 analog

This paper develops and validates a near-infrared optoacoustic contrast agent for imaging GLP-1R-expressing cells in vivo.

The common analgesic paracetamol enhances the anti-tumour activity of decitabine through exacerbation of oxidative stress

This study shows that paracetamol enhances decitabine's anti-tumour effects by increasing oxidative stress without worsening DNA damage.

Social bonding, gestural complexity and displacement behaviour of wild chimpanzee

This study examines how gestural communication in wild chimpanzees affects social affiliation, finding that affiliative gestures predict social bonding while contexts vary in their association with gesture complexity and displacement behavior.

The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells

This study shows that the WT1-BASP1 complex maintains the differentiated state of taste receptor cells by inhibiting WT1-dependent gene activation in adult mice.

Intentional gestures predict complex sociality in wild chimpanzee

The paper examines how intentional gestures in wild chimpanzees correlate with social complexity, finding that persistent gestures are linked to longer proximity and central social network positions.