Author

J. M. Boss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

C. D. Scharer· 3 shared I. Sanz· 3 shared A. Nellore· 2 shared A. Rosenberg· 2 shared B. Mousseau· 2 shared E. Zumaquero· 2 shared F. E. Lund· 2 shared J. E. Bradley· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

C. D. Scharer

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Author profile →

5 papers

Recent·Most cited

Aiolos modulates the TFH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25

K. A. Read, D. M. Jones, S. Pokhrel, E. D. S. Hales, A. Varkey, J. A. Tuazon, C. D. Eisele, O. Abdouni, A. Saadey, R. T. Warren, M. D. Powell, J. M. Boss, E. A. Hemann, J. S. Yount, H. E. Ghoneim, , K. J. Oestreich

This study identifies Aiolos as a regulator of TFH and CD4-CTL differentiation, showing it modulates the Zfp831/TCF-1/Bcl-6 axis and suppresses the cytotoxic gene program.

bioRxiv · May 18, 2022 · PreprintImmunology

An IRF4-MYC-mTORC1 integrated pathway controls cell growth and the proliferative capacity of activated B cells during B cell differentiation in vivo

D. G. Patterson, A. K. Kania, M. J. Price, J. R. Rose, C. D. Scharer, J. M. Boss

This study identifies an IRF4-MYC-mTORC1 pathway critical for B cell proliferation and growth during differentiation, showing IRF4 regulates MYC and mTORC1 to drive metabolic reprogramming and cell cycle progression.

bioRxiv · Jun 20, 2021Immunology

Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic Regulation

C. J. Joyner, A. Ley, D. Nguyen, M. Ali, A. Corrado, C. Tipton, C. Scharer, T. Mi, M. C. Woodruff, J. Hom, J. M. Boss, M. Duan, G. Gibson, D. Roberts, J. Andrews, , F. E.-H. Lee

This study shows human blood ASCs undergo transcriptional and epigenetic changes in the BM microniche to become apoptotic-resistant LLPC.

bioRxiv · May 22, 2021 · PreprintImmunology

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

A. Nellore, E. Zumaquero, C. D. Scharer, R. G. King, C. M. Tipton, C. Fucile, B. Mousseau, J. E. Bradley, T. Mi, P. A. Goepfert, J. F. Kearney, J. M. Boss, T. D. Randall, I. Sanz, A. Rosenberg, F. E. Lund

The paper identifies T-bethi Bmem cells as predictors of long-lived antibody responses to influenza vaccination in humans.

bioRxiv · Feb 18, 2021 · PreprintImmunology

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

E. Zumaquero, S. L. Stone, C. D. Scharer, S. A. Jenks, A. Nellore, B. Mousseau, A. Rosal-Vela, D. Botta, J. E. Bradley, W. Wojciechowski, T. Ptacek, M. I. Danila, J. C. Edberg, S. L. Bridges, R. P. Kimberly, , F. E. Lund

This study shows IFNγ promotes T-bet expressing B cell differentiation and epigenetic reprogramming in humans, enhancing IL-21-driven antibody production.

bioRxiv · Feb 21, 2019Immunology